In Vivo Reversal of P-Glycoprotein-Mediated Drug Resistance in a Breast Cancer Xenograft and in Leukemia Models Using a Novel, Potent, and Nontoxic Epicatechin EC31

The modulation of P-glycoprotein (P-gp, ABCB1) can reverse multidrug resistance (MDR) and potentiate the efficacy of anticancer drugs. Tea polyphenols, such as epigallocatechin gallate (EGCG), have low P-gp-modulating activity, with an EC(50) over 10 μM. In this study, we optimized a series of tea p...

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Detalles Bibliográficos
Autores principales: Sun, Wenqin, Wong, Iris L. K., Law, Helen Ka-Wai, Su, Xiaochun, Chan, Terry C. F., Sun, Gege, Yang, Xinqing, Wang, Xingkai, Chan, Tak Hang, Wan, Shengbiao, Chow, Larry M. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002220/
https://www.ncbi.nlm.nih.gov/pubmed/36901808
http://dx.doi.org/10.3390/ijms24054377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002220/
https://www.ncbi.nlm.nih.gov/pubmed/36901808
http://dx.doi.org/10.3390/ijms24054377

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