Cargando…
In Vivo Reversal of P-Glycoprotein-Mediated Drug Resistance in a Breast Cancer Xenograft and in Leukemia Models Using a Novel, Potent, and Nontoxic Epicatechin EC31
The modulation of P-glycoprotein (P-gp, ABCB1) can reverse multidrug resistance (MDR) and potentiate the efficacy of anticancer drugs. Tea polyphenols, such as epigallocatechin gallate (EGCG), have low P-gp-modulating activity, with an EC(50) over 10 μM. In this study, we optimized a series of tea p...
Autores principales: | Sun, Wenqin, Wong, Iris L. K., Law, Helen Ka-Wai, Su, Xiaochun, Chan, Terry C. F., Sun, Gege, Yang, Xinqing, Wang, Xingkai, Chan, Tak Hang, Wan, Shengbiao, Chow, Larry M. C. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002220/ https://www.ncbi.nlm.nih.gov/pubmed/36901808 http://dx.doi.org/10.3390/ijms24054377 |
Ejemplares similares
-
Browning of Epicatechin (EC) and Epigallocatechin (EGC) by Auto-Oxidation
por: Tan, Junfeng, et al.
Publicado: (2020) -
Discovery of a Flavonoid FM04 as a Potent Inhibitor to Reverse P-Glycoprotein-Mediated Drug Resistance in Xenografts and Improve Oral Bioavailability of Paclitaxel
por: Kan, Jason W. Y., et al.
Publicado: (2022) -
Nontoxic Neonates
por: Washam, C
Publicado: (2002) -
Nontoxic electron collimators
por: Breitkreutz, Dylan Yamabe, et al.
Publicado: (2021) -
The LIFR-targeting small molecules EC330/EC359 are potent ferroptosis inducers
por: Feng, Chang-Zhou, et al.
Publicado: (2022)