The CaSR Modulator NPS-2143 Reduced UV-Induced DNA Damage in Skh:hr1 Hairless Mice but Minimally Inhibited Skin Tumours

The calcium-sensing receptor (CaSR) is an important regulator of epidermal function. We previously reported that knockdown of the CaSR or treatment with its negative allosteric modulator, NPS-2143, significantly reduced UV-induced DNA damage, a key factor in skin cancer development. We subsequently...

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Detalles Bibliográficos
Autores principales: Yang, Chen, Rybchyn, Mark Stephen, De Silva, Warusavithana Gunawardena Manori, Matthews, Jim, Dixon, Katie Marie, Holland, Andrew J. A., Conigrave, Arthur David, Mason, Rebecca Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002576/
https://www.ncbi.nlm.nih.gov/pubmed/36902353
http://dx.doi.org/10.3390/ijms24054921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002576/
https://www.ncbi.nlm.nih.gov/pubmed/36902353
http://dx.doi.org/10.3390/ijms24054921

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