Expression Dynamics of CA IX Epitope in Cancer Cells under Intermittent Hypoxia Correlates with Extracellular pH Drop and Cell Killing by Ureido-Sulfonamide CA IX Inhibitors

Carbonic anhydrase IX (CA IX) is a membrane-bound CA isozyme over-expressed in many hypoxic tumor cells, where it ensures pH homeostasis and has been implicated in tumor survival, metastasis and resistance to chemotherapy and radiotherapy. Given the functional importance of CA IX in tumor biochemist...

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Detalles Bibliográficos
Autores principales: Sufian, Md. Abu, Zamanova, Sabina, Shabana, Ahmed M., Kemp, Brianna, Mondal, Utpal K., Supuran, Claudiu T., Ilies, Marc A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002582/
https://www.ncbi.nlm.nih.gov/pubmed/36902027
http://dx.doi.org/10.3390/ijms24054595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002582/
https://www.ncbi.nlm.nih.gov/pubmed/36902027
http://dx.doi.org/10.3390/ijms24054595

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