Role of Ganetespib, an HSP90 Inhibitor, in Cancer Therapy: From Molecular Mechanisms to Clinical Practice

Heat-shock proteins are upregulated in cancer and protect several client proteins from degradation. Therefore, they contribute to tumorigenesis and cancer metastasis by reducing apoptosis and enhancing cell survival and proliferation. These client proteins include the estrogen receptor (ER), epiderm...

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Detalles Bibliográficos
Autores principales: Youssef, Mahmoud E., Cavalu, Simona, Hasan, Alexandru Madalin, Yahya, Galal, Abd-Eldayem, Marwa A., Saber, Sameh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002602/
https://www.ncbi.nlm.nih.gov/pubmed/36902446
http://dx.doi.org/10.3390/ijms24055014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002602/
https://www.ncbi.nlm.nih.gov/pubmed/36902446
http://dx.doi.org/10.3390/ijms24055014

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