Widespread epistasis shapes RNA Polymerase II active site function and evolution

Multi-subunit RNA Polymerases (msRNAPs) are responsible for transcription in all kingdoms of life. At the heart of these msRNAPs is an ultra-conserved active site domain, the trigger loop (TL), coordinating transcription speed and fidelity by critical conformational changes impacting multiple steps...

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Detalles Bibliográficos
Autores principales: Duan, Bingbing, Qiu, Chenxi, Sze, Sing-Hoi, Kaplan, Craig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002619/
https://www.ncbi.nlm.nih.gov/pubmed/36909581
http://dx.doi.org/10.1101/2023.02.27.530048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002619/
https://www.ncbi.nlm.nih.gov/pubmed/36909581
http://dx.doi.org/10.1101/2023.02.27.530048

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