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A Conserved Requirement for RME-8/DNAJC13 in Neuronal Autolysosome Reformation

Autophagosomes fuse with lysosomes, forming autolysosomes that degrade engulfed cargo. To maintain lysosomal capacity, autolysosome reformation (ALR) must regenerate lysosomes from autolysosomes using a membrane tubule-based process. Maintaining lysosomal capacity is required to maintain proteostasi...

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Detalles Bibliográficos
Autores principales: Swords, Sierra, Jia, Nuo, Norris, Anne, Modi, Jil, Cai, Qian, Grant, Barth D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002637/
https://www.ncbi.nlm.nih.gov/pubmed/36909501
http://dx.doi.org/10.1101/2023.02.27.530319