SIRT6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes

While advanced age has long been recognized as the greatest risk factor for osteoarthritis (OA), the biological mechanisms behind this connection remain unclear. Previous work has demonstrated that chondrocytes from older cadaveric donors have elevated levels of DNA damage as compared to chondrocyte...

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Detalles Bibliográficos
Autores principales: Copp, Michaela E., Shine, Jacqueline, Brown, Hannon L., Nimmala, Kirti R., Chubinskaya, Susan, Collins, John A., Loeser, Richard F., Diekman, Brian O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002640/
https://www.ncbi.nlm.nih.gov/pubmed/36909504
http://dx.doi.org/10.1101/2023.02.27.530205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002640/
https://www.ncbi.nlm.nih.gov/pubmed/36909504
http://dx.doi.org/10.1101/2023.02.27.530205

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