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SIRT6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes
While advanced age has long been recognized as the greatest risk factor for osteoarthritis (OA), the biological mechanisms behind this connection remain unclear. Previous work has demonstrated that chondrocytes from older cadaveric donors have elevated levels of DNA damage as compared to chondrocyte...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002640/ https://www.ncbi.nlm.nih.gov/pubmed/36909504 http://dx.doi.org/10.1101/2023.02.27.530205 |