Leveraging IFNγ/CD38 regulation to unmask and target leukemia stem cells in acute myelogenous leukemia

Elimination of drug-resistant leukemia stem cells (LSCs) represents a major challenge to achieve a cure in acute myeloid leukemia (AML). Although AML blasts generally retain high levels of surface CD38 (CD38(pos)), the presence of CD34 and lack of CD38 expression (CD34(pos)CD38(neg)) are immunopheno...

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Detalles Bibliográficos
Autores principales: Murtadha, Mariam, Park, Miso, Zhu, Yinghui, Caserta, Enrico, Dona, Ada Alice, Singer, Mahmoud, Vahed, Hawa, Tasndoh, Theophilus, Gonzalez, Asaul, Ly, Kevin, Sanchez, James F, Chowdhury, Arnab, Pozhitkov, Alex, Ghoda, Lucy, Li, Ling, Zhang, Bin, Krishnan, Amrita, Marcucci, Guido, Williams, John, Pichiorri, Flavia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002674/
https://www.ncbi.nlm.nih.gov/pubmed/36909542
http://dx.doi.org/10.1101/2023.02.27.530273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002674/
https://www.ncbi.nlm.nih.gov/pubmed/36909542
http://dx.doi.org/10.1101/2023.02.27.530273

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