UBE3A and transsynaptic complex NRXN1-CBLN1-GluD1 in a hypothalamic VMHvl-arcuate feedback circuit regulates aggression

The circuit origins of aggression in autism spectrum disorder remain undefined. Here we report Tac1-expressing glutamatergic neurons in ventrolateral division of ventromedial hypothalamus (VMHvl) drive intermale aggression. Aggression is increased due to increases of Ube3a gene dosage in the VMHvl n...

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Detalles Bibliográficos
Autores principales: Nong, Yi, Stoppel, David C., Johnson, Mark A., Boillot, Morgane, Todorovic, Jelena, Shen, Jason, Zhou, Xinyu, Nadler, Monica J.S., Rodriguez, Carrie, Huo, Yuda, Nagakura, Ikue, Kasper, Ekkehard M., Anderson, Matthew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002692/
https://www.ncbi.nlm.nih.gov/pubmed/36909588
http://dx.doi.org/10.1101/2023.02.28.530462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002692/
https://www.ncbi.nlm.nih.gov/pubmed/36909588
http://dx.doi.org/10.1101/2023.02.28.530462

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