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Interpreting population and family-based genome-wide association studies in the presence of confounding

A central aim of genome-wide association studies (GWASs) is to estimate direct genetic effects: the causal effects on an individual’s phenotype of the alleles that they carry. However, estimates of direct effects can be subject to genetic and environmental confounding, and can also absorb the ‘indir...

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Detalles Bibliográficos
Autores principales: Veller, Carl, Coop, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002712/
https://www.ncbi.nlm.nih.gov/pubmed/36909521
http://dx.doi.org/10.1101/2023.02.26.530052