CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment

Germline CTLA-4 deficiency causes severe autoimmune diseases characterized by dysregulation of Foxp3(+) Tregs, hyper-activation of effector memory T cells, and variable forms autoimmune cytopenia including gradual loss of B cells. Cancer patients with severe immune-related adverse events (irAE) afte...

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Detalles Bibliográficos
Autores principales: Muthana, Musleh M., Du, Xuexiang, Liu, Mingyue, Wang, Xu, Wu, Wei, Ai, Chunxia, Su, Lishan, Zheng, Pan, Liu, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002750/
https://www.ncbi.nlm.nih.gov/pubmed/36909522
http://dx.doi.org/10.1101/2023.03.01.530608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002750/
https://www.ncbi.nlm.nih.gov/pubmed/36909522
http://dx.doi.org/10.1101/2023.03.01.530608

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