Logic-based mechanistic machine learning on high-content images reveals how drugs differentially regulate cardiac fibroblasts

Fibroblasts are essential regulators of extracellular matrix deposition following cardiac injury. These cells exhibit highly plastic responses in phenotype during fibrosis in response to environmental stimuli. Here, we test whether and how candidate anti-fibrotic drugs differentially regulate measur...

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Detalles Bibliográficos
Autores principales: Nelson, Anders R., Christiansen, Steven L., Naegle, Kristen M., Saucerman, Jeffrey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002757/
https://www.ncbi.nlm.nih.gov/pubmed/36909540
http://dx.doi.org/10.1101/2023.03.01.530599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002757/
https://www.ncbi.nlm.nih.gov/pubmed/36909540
http://dx.doi.org/10.1101/2023.03.01.530599

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