Nuclear Smooth Muscle α-actin in Vascular Smooth Muscle Cell Differentiation

Missense variants throughout ACTA2, encoding smooth muscle α-actin (αSMA), predispose to adult onset thoracic aortic disease, but variants disrupting arginine 179 (R179) lead to Smooth Muscle Dysfunction Syndrome (SMDS) characterized by childhood-onset diverse vascular diseases. Our data indicate th...

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Detalles Bibliográficos
Autores principales: Kwartler, Callie S., Pedroza, Albert J., Kaw, Anita, Guan, Pujun, Ma, Shuangtao, Duan, Xue-yan, Kernell, Caroline, Wang, Charis, Pinelo, Jose Emiliano Esparza, Borthwick, Mikayla S., Chen, Jiyuan, Zhong, Yuan, Sinha, Sanjay, Shen, Xuetong, Fischbein, Michael P., Milewicz, Dianna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002808/
https://www.ncbi.nlm.nih.gov/pubmed/36909460
http://dx.doi.org/10.21203/rs.3.rs-1623114/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002808/
https://www.ncbi.nlm.nih.gov/pubmed/36909460
http://dx.doi.org/10.21203/rs.3.rs-1623114/v1

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