Pathway-specific polygenic risk scores correlate with clinical status and Alzheimer’s-related biomarkers

BACKGROUND: APOE is the largest genetic risk factor for sporadic Alzheimer’s disease (AD), but there is a substantial polygenic component as well. Polygenic risk scores (PRS) can summarize small effects across the genome but may obscure differential risk associated with different molecular processes...

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Detalles Bibliográficos
Autores principales: Schork, Nicholas J., Elman, Jeremy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002839/
https://www.ncbi.nlm.nih.gov/pubmed/36909609
http://dx.doi.org/10.21203/rs.3.rs-2583037/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002839/
https://www.ncbi.nlm.nih.gov/pubmed/36909609
http://dx.doi.org/10.21203/rs.3.rs-2583037/v1

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