Cargando…
Pathway-specific polygenic risk scores correlate with clinical status and Alzheimer’s-related biomarkers
BACKGROUND: APOE is the largest genetic risk factor for sporadic Alzheimer’s disease (AD), but there is a substantial polygenic component as well. Polygenic risk scores (PRS) can summarize small effects across the genome but may obscure differential risk associated with different molecular processes...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Journal Experts
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002839/ https://www.ncbi.nlm.nih.gov/pubmed/36909609 http://dx.doi.org/10.21203/rs.3.rs-2583037/v1 |