Endothelin-1 Induces Cell Proliferation and Myofibroblast Differentiation through the ET(A)R/G(αq)/ERK Signaling Pathway in Human Cardiac Fibroblasts

Endothelin-1 (ET-1) has been implicated in the pathogenesis of cardiac fibrosis. Stimulation of endothelin receptors (ETR) with ET-1 leads to fibroblast activation and myofibroblast differentiation, which is mainly characterized by an overexpression of α-smooth muscle actin (α-SMA) and collagens. Al...

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Detalles Bibliográficos
Autores principales: Duangrat, Ratchanee, Parichatikanond, Warisara, Likitnukul, Sutharinee, Mangmool, Supachoke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002923/
https://www.ncbi.nlm.nih.gov/pubmed/36901906
http://dx.doi.org/10.3390/ijms24054475

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002923/
https://www.ncbi.nlm.nih.gov/pubmed/36901906
http://dx.doi.org/10.3390/ijms24054475

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