Dual PTP1B/TC-PTP Inhibitors: Biological Evaluation of 3-(Hydroxymethyl)cinnoline-4(1H)-Ones

Dual inhibitors of protein phosphotyrosine phosphatase 1B (PTP1B)/T-cell protein phosphotyrosine phosphatase (TC-PTP) based on the 3-(hydroxymethyl)-4-oxo-1,4-dihydrocinnoline scaffold have been identified. Their dual affinity to both enzymes has been thoroughly corroborated by in silico modeling ex...

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Detalles Bibliográficos
Autores principales: Derkach, Kira V., Gureev, Maxim A., Babushkina, Anastasia A., Mikhaylov, Vladimir N., Zakharova, Irina O., Bakhtyukov, Andrey A., Sorokoumov, Viktor N., Novikov, Alexander S., Krasavin, Mikhail, Shpakov, Alexander O., Balova, Irina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002984/
https://www.ncbi.nlm.nih.gov/pubmed/36901928
http://dx.doi.org/10.3390/ijms24054498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002984/
https://www.ncbi.nlm.nih.gov/pubmed/36901928
http://dx.doi.org/10.3390/ijms24054498

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