MKP-1 Deficiency Exacerbates Skin Fibrosis in a Mouse Model of Scleroderma

Scleroderma is a chronic fibrotic disease, where proinflammatory and profibrotic events precede collagen accumulation. MKP-1 [mitogen-activated protein kinase (MAPK) phosphatase-1] downregulates inflammatory MAPK pathways suppressing inflammation. MKP-1 also supports Th1 polarization, which could sh...

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Detalles Bibliográficos
Autores principales: Scotece, Morena, Hämäläinen, Mari, Leppänen, Tiina, Vuolteenaho, Katriina, Moilanen, Eeva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002998/
https://www.ncbi.nlm.nih.gov/pubmed/36902103
http://dx.doi.org/10.3390/ijms24054668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002998/
https://www.ncbi.nlm.nih.gov/pubmed/36902103
http://dx.doi.org/10.3390/ijms24054668

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