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MKP-1 Deficiency Exacerbates Skin Fibrosis in a Mouse Model of Scleroderma

Scleroderma is a chronic fibrotic disease, where proinflammatory and profibrotic events precede collagen accumulation. MKP-1 [mitogen-activated protein kinase (MAPK) phosphatase-1] downregulates inflammatory MAPK pathways suppressing inflammation. MKP-1 also supports Th1 polarization, which could sh...

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Detalles Bibliográficos
Autores principales:	Scotece, Morena, Hämäläinen, Mari, Leppänen, Tiina, Vuolteenaho, Katriina, Moilanen, Eeva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002998/ https://www.ncbi.nlm.nih.gov/pubmed/36902103 http://dx.doi.org/10.3390/ijms24054668

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