Selectivity of Hydroxamate- and Difluoromethyloxadiazole-Based Inhibitors of Histone Deacetylase 6 In Vitro and in Cells

Histone deacetylase 6 (HDAC6) is a unique member of the HDAC family of enzymes due to its complex domain organization and cytosolic localization. Experimental data point toward the therapeutic use of HDAC6-selective inhibitors (HDAC6is) for use in both neurological and psychiatric disorders. In this...

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Detalles Bibliográficos
Autores principales: Ptacek, Jakub, Snajdr, Ivan, Schimer, Jiri, Kutil, Zsofia, Mikesova, Jana, Baranova, Petra, Havlinova, Barbora, Tueckmantel, Werner, Majer, Pavel, Kozikowski, Alan, Barinka, Cyril
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003107/
https://www.ncbi.nlm.nih.gov/pubmed/36902164
http://dx.doi.org/10.3390/ijms24054720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003107/
https://www.ncbi.nlm.nih.gov/pubmed/36902164
http://dx.doi.org/10.3390/ijms24054720

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