Engineering of DNA Structures Attached to Magnetic Particles for Effective Trans- and Cis-Cleavage in Cas12-Based Biosensors

Sequence-specific endonuclease Cas12-based biosensors have rapidly evolved as a strong tool to detect nucleic acids. Magnetic particles (MPs) with attached DNA structures could be used as a universal platform to manipulate the DNA-cleavage activity of Cas12. Here, we propose nanostructures of trans-...

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Detalles Bibliográficos
Autores principales: Ivanov, Aleksandr V., Safenkova, Irina V., Biketov, Sergey F., Zherdev, Anatoly V., Dzantiev, Boris B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003267/
https://www.ncbi.nlm.nih.gov/pubmed/36901914
http://dx.doi.org/10.3390/ijms24054484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003267/
https://www.ncbi.nlm.nih.gov/pubmed/36901914
http://dx.doi.org/10.3390/ijms24054484

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