Effective, Rapid, and Small-Scale Bioconjugation and Purification of “Clicked” Small-Molecule DNA Oligonucleotide for Nucleic Acid Nanoparticle Functionalization

Nucleic acid-based therapeutics involves the conjugation of small molecule drugs to nucleic acid oligomers to surmount the challenge of solubility, and the inefficient delivery of these drug molecules into cells. “Click” chemistry has become popular conjugation approach due to its simplicity and hig...

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Detalles Bibliográficos
Autores principales: Doe, Erwin, Hayth, Hannah L., Brumett, Ross, Khisamutdinov, Emil F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003352/
https://www.ncbi.nlm.nih.gov/pubmed/36902228
http://dx.doi.org/10.3390/ijms24054797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003352/
https://www.ncbi.nlm.nih.gov/pubmed/36902228
http://dx.doi.org/10.3390/ijms24054797

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