Probing the E1o-E2o and E1a-E2o Interactions in Binary Subcomplexes of the Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Complexes by Chemical Cross-Linking Mass Spectrometry and Molecular Dynamics Simulation

The human 2-oxoglutarate dehydrogenase complex (hOGDHc) is a key enzyme in the tricarboxylic acid cycle and is one of the main regulators of mitochondrial metabolism through NADH and reactive oxygen species levels. Evidence was obtained for formation of a hybrid complex between the hOGDHc and its ho...

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Detalles Bibliográficos
Autores principales: Ozohanics, Oliver, Zhang, Xu, Nemeria, Natalia S., Ambrus, Attila, Jordan, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003691/
https://www.ncbi.nlm.nih.gov/pubmed/36901986
http://dx.doi.org/10.3390/ijms24054555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003691/
https://www.ncbi.nlm.nih.gov/pubmed/36901986
http://dx.doi.org/10.3390/ijms24054555

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