Probing the Mechanisms of Inhibitors Binding to Presenilin Homologue Using Molecular Dynamics Simulations

γ-secretase is an intramembrane proteolytic enzyme that is mainly involved in the cleavage and hydrolysis of the amyloid precursor (APP). The catalytic subunit presenilin 1 (PS1) is the catalytic subunit of γ-secretase. Since it was found that PS1 is responsible for Aβ-producing proteolytic activity...

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Detalles Bibliográficos
Autores principales: Wang, Min, Liu, Kaifeng, Ma, Yingying, Han, Weiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004098/
https://www.ncbi.nlm.nih.gov/pubmed/36903320
http://dx.doi.org/10.3390/molecules28052076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004098/
https://www.ncbi.nlm.nih.gov/pubmed/36903320
http://dx.doi.org/10.3390/molecules28052076

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