Exploration of Pyrido[3,4-d]pyrimidines as Antagonists of the Human Chemokine Receptor CXCR2

Upregulated CXCR2 signalling is found in numerous inflammatory, autoimmune and neurodegenerative diseases, as well as in cancer. Consequently, CXCR2 antagonism is a promising therapeutic strategy for treatment of these disorders. We previously identified, via scaffold hopping, a pyrido[3,4-d]pyrimid...

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Detalles Bibliográficos
Autores principales: Van Hoof, Max, Claes, Sandra, Boon, Katrijn, Van Loy, Tom, Schols, Dominique, Dehaen, Wim, De Jonghe, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004157/
https://www.ncbi.nlm.nih.gov/pubmed/36903345
http://dx.doi.org/10.3390/molecules28052099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004157/
https://www.ncbi.nlm.nih.gov/pubmed/36903345
http://dx.doi.org/10.3390/molecules28052099

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