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Identification of residues involved in allosteric signal transmission from amino acid binding site of pyruvate kinase muscle isoform 2
PKM2 is a rate-limiting enzyme in the glycolytic process and is involved in regulating tumor proliferation. Several amino acids (AAs) such as Asn, Asp, Val, and Cys have been shown to bind to the AA binding pocket of PKM2 and modulate its oligomeric state, substrate binding affinity, and activity. A...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004559/ https://www.ncbi.nlm.nih.gov/pubmed/36897854 http://dx.doi.org/10.1371/journal.pone.0282508 |