Mitotic CDK1 and 4E-BP1 II: A single phosphomimetic mutation in 4E-BP1 induces glucose intolerance in mice

OBJECTIVE: Cyclin-dependent kinase 1 (CDK1)/cyclin B1 phosphorylates many of the same substrates as mTORC1 (a key regulator of glucose metabolism), including the eukaryotic initiation factor 4E-binding protein 1 (4E-BP1). Only mitotic CDK1 phosphorylates 4E-BP1 at residue S82 in mice (S83 in humans)...

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Detalles Bibliográficos
Autores principales: Cao, Simon, Jurczak, Michael J., Shuda, Yoko, Sun, Rui, Shuda, Masahiro, Chang, Yuan, Moore, Patrick S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004604/
https://www.ncbi.nlm.nih.gov/pubmed/36897840
http://dx.doi.org/10.1371/journal.pone.0282914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004604/
https://www.ncbi.nlm.nih.gov/pubmed/36897840
http://dx.doi.org/10.1371/journal.pone.0282914

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