Development and Validation of a Rapid LC-MS/MS Method for Quantifying Alvocidib: In Silico and In Vitro Metabolic Stability Estimation in Human Liver Microsomes

Alvocidib (AVC; flavopiridol) is a potent cyclin-dependent kinase inhibitor used in patients with acute myeloid leukemia (AML). The FDA has approved orphan drug designation to AVC for treating patients with AML. In the current work, the in silico calculation of AVC metabolic lability was done using...

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Detalles Bibliográficos
Autores principales: Attwa, Mohamed W., AlRabiah, Haitham, Kadi, Adnan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004750/
https://www.ncbi.nlm.nih.gov/pubmed/36903615
http://dx.doi.org/10.3390/molecules28052368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004750/
https://www.ncbi.nlm.nih.gov/pubmed/36903615
http://dx.doi.org/10.3390/molecules28052368

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