Rational Computational Approaches in Drug Discovery: Potential Inhibitors for Allosteric Regulation of Mutant Isocitrate Dehydrogenase-1 Enzyme in Cancers

Mutations in homodimeric isocitrate dehydrogenase (IDH) enzymes at specific arginine residues result in the abnormal activity to overproduce D-2 hydroxyglutarate (D-2HG), which is often projected as solid oncometabolite in cancers and other disorders. As a result, depicting the potential inhibitor f...

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Detalles Bibliográficos
Autores principales: Thamim, Masthan, Agrahari, Ashish Kumar, Gupta, Pawan, Thirumoorthy, Krishnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005488/
https://www.ncbi.nlm.nih.gov/pubmed/36903561
http://dx.doi.org/10.3390/molecules28052315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005488/
https://www.ncbi.nlm.nih.gov/pubmed/36903561
http://dx.doi.org/10.3390/molecules28052315

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