Development of an LC-MS/MS Method for Quantification of Sapitinib in Human Liver Microsomes: In Silico and In Vitro Metabolic Stability Evaluation

Sapitinib (AZD8931, SPT) is a tyrosine kinase inhibitor of the epidermal growth factor receptor (EGFR) family (pan-erbB). In multiple tumor cell lines, STP has been shown to be a much more potent inhibitor of EGF-driven cellular proliferation than gefitinib. In the current study, a highly sensitive,...

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Detalles Bibliográficos
Autores principales: Attwa, Mohamed W., AlRabiah, Haitham, Mostafa, Gamal A. E., Kadi, Adnan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005647/
https://www.ncbi.nlm.nih.gov/pubmed/36903565
http://dx.doi.org/10.3390/molecules28052322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005647/
https://www.ncbi.nlm.nih.gov/pubmed/36903565
http://dx.doi.org/10.3390/molecules28052322

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