Development of a Rapid LC-MS/MS Method for Simultaneous Quantification of Donepezil and Tadalafil in Rat Plasma: Its Application in a Pharmacokinetic Interaction Study after Oral Administration in Rats

This study aimed to establish a simple and sensitive analytical method to simultaneously quantify donepezil (DPZ) and tadalafil (TAD) in rat plasma using lansoprazole (LPZ) as an internal standard (IS) by using liquid chromatography tandem mass spectrometry. The fragmentation pattern of DPZ, TAD, an...

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Detalles Bibliográficos
Autores principales: Yoon, Jiyoung, Choi, Doowon, Shim, Wang-Seob, Choi, Sanghee, Choi, Yeo Jin, Paik, Soo-Heui, Lee, Kyung-Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005750/
https://www.ncbi.nlm.nih.gov/pubmed/36903595
http://dx.doi.org/10.3390/molecules28052352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005750/
https://www.ncbi.nlm.nih.gov/pubmed/36903595
http://dx.doi.org/10.3390/molecules28052352

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