Efficient Synthesis of 1H-Benzo[4,5]imidazo[1,2-c][1,3]oxazin-1-one Derivatives Using Ag(2)CO(3)/TFA-Catalyzed 6-endo-dig Cyclization: Reaction Scope and Mechanistic Study

A small library of 1H-benzo[4,5]imidazo[1,2-c][1,3]oxazin-1-one derivatives was prepared in good to excellent yields, involving a Ag(2)CO(3)/TFA-catalyzed intramolecular oxacyclization of N-Boc-2-alkynylbenzimidazole substrates. In all experiments, the 6-endo-dig cyclization was exclusively achieved...

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Detalles Bibliográficos
Autores principales: El Qami, Abdelkarim, Jismy, Badr, Akssira, Mohamed, Jacquemin, Johan, Tikad, Abdellatif, Abarbri, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005794/
https://www.ncbi.nlm.nih.gov/pubmed/36903655
http://dx.doi.org/10.3390/molecules28052403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005794/
https://www.ncbi.nlm.nih.gov/pubmed/36903655
http://dx.doi.org/10.3390/molecules28052403

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