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Efficient Synthesis of 1H-Benzo[4,5]imidazo[1,2-c][1,3]oxazin-1-one Derivatives Using Ag(2)CO(3)/TFA-Catalyzed 6-endo-dig Cyclization: Reaction Scope and Mechanistic Study
A small library of 1H-benzo[4,5]imidazo[1,2-c][1,3]oxazin-1-one derivatives was prepared in good to excellent yields, involving a Ag(2)CO(3)/TFA-catalyzed intramolecular oxacyclization of N-Boc-2-alkynylbenzimidazole substrates. In all experiments, the 6-endo-dig cyclization was exclusively achieved...
Autores principales: | El Qami, Abdelkarim, Jismy, Badr, Akssira, Mohamed, Jacquemin, Johan, Tikad, Abdellatif, Abarbri, Mohamed |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005794/ https://www.ncbi.nlm.nih.gov/pubmed/36903655 http://dx.doi.org/10.3390/molecules28052403 |
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