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Safety and immunogenicity of the group B streptococcus vaccine AlpN in a placebo-controlled double-blind phase 1 trial

Group B streptococcus (GBS) is a leading cause of life-threatening neonatal infections and subsets of adverse pregnancy outcomes. Essentially all GBS strains possess one allele of the alpha-like protein (Alp) family. A maternal GBS vaccine, consisting of the fused N-terminal domains of the Alps αC a...

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Detalles Bibliográficos
Autores principales: Gonzalez-Miro, Majela, Pawlowski, Andrzej, Lehtonen, Janne, Cao, Duojia, Larsson, Sara, Darsley, Michael, Kitson, Geoff, Fischer, Per B., Johansson-Lindbom, Bengt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005905/
https://www.ncbi.nlm.nih.gov/pubmed/36915681
http://dx.doi.org/10.1016/j.isci.2023.106261