Hydroxychloroquine lowers Alzheimer’s disease and related dementias risk and rescues molecular phenotypes related to Alzheimer’s disease

We recently nominated cytokine signaling through the Janus-kinase–signal transducer and activator of transcription (JAK/STAT) pathway as a potential AD drug target. As hydroxychloroquine (HCQ) has recently been shown to inactivate STAT3, we hypothesized that it may impact AD pathogenesis and risk. A...

Descripción completa

Detalles Bibliográficos
Autores principales: Varma, Vijay R., Desai, Rishi J., Navakkode, Sheeja, Wong, Lik-Wei, Anerillas, Carlos, Loeffler, Tina, Schilcher, Irene, Mahesri, Mufaddal, Chin, Kristyn, Horton, Daniel B., Kim, Seoyoung C., Gerhard, Tobias, Segal, Jodi B., Schneeweiss, Sebastian, Gorospe, Myriam, Sajikumar, Sreedharan, Thambisetty, Madhav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005941/
https://www.ncbi.nlm.nih.gov/pubmed/36577843
http://dx.doi.org/10.1038/s41380-022-01912-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005941/
https://www.ncbi.nlm.nih.gov/pubmed/36577843
http://dx.doi.org/10.1038/s41380-022-01912-0

Ejemplares similares