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Hydroxychloroquine lowers Alzheimer’s disease and related dementias risk and rescues molecular phenotypes related to Alzheimer’s disease

We recently nominated cytokine signaling through the Janus-kinase–signal transducer and activator of transcription (JAK/STAT) pathway as a potential AD drug target. As hydroxychloroquine (HCQ) has recently been shown to inactivate STAT3, we hypothesized that it may impact AD pathogenesis and risk. A...

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Detalles Bibliográficos
Autores principales:	Varma, Vijay R., Desai, Rishi J., Navakkode, Sheeja, Wong, Lik-Wei, Anerillas, Carlos, Loeffler, Tina, Schilcher, Irene, Mahesri, Mufaddal, Chin, Kristyn, Horton, Daniel B., Kim, Seoyoung C., Gerhard, Tobias, Segal, Jodi B., Schneeweiss, Sebastian, Gorospe, Myriam, Sajikumar, Sreedharan, Thambisetty, Madhav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005941/ https://www.ncbi.nlm.nih.gov/pubmed/36577843 http://dx.doi.org/10.1038/s41380-022-01912-0

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