The expression of fibrosis-related genes is elevated in doxorubicin-induced senescent human dermal fibroblasts, but their secretome does not trigger a paracrine fibrotic response in non-senescent cells

Tissue fibrosis is associated with the aging process of most of our organs, and organ aging correlates with the chronic accumulation of senescent cells. Fibrosis occurs when fibroblasts proliferate and deposit pathological amounts of extracellular matrix (ECM), leading to progressive tissue scarring...

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Detalles Bibliográficos
Autores principales: Nosrati, Fariba, Grillari, Johannes, Azarnia, Mahnaz, Nabiuni, Mohammad, Moghadasali, Reza, Karimzadeh, Latifeh, Lämmermann, Ingo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006027/
https://www.ncbi.nlm.nih.gov/pubmed/36648709
http://dx.doi.org/10.1007/s10522-022-10013-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006027/
https://www.ncbi.nlm.nih.gov/pubmed/36648709
http://dx.doi.org/10.1007/s10522-022-10013-y

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