Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence

Vascular endothelial cells (ECs) senescence correlates with the increase of cardiovascular diseases in ageing population. Although ECs rely on glycolysis for energy production, little is known about the role of glycolysis in ECs senescence. Here, we report a critical role for glycolysis-derived seri...

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Detalles Bibliográficos
Autores principales: Wu, Yinsheng, Tang, Lixu, Huang, Han, Yu, Qi, Hu, Bicheng, Wang, Gang, Ge, Feng, Yin, Tailang, Li, Shanshan, Yu, Xilan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006232/
https://www.ncbi.nlm.nih.gov/pubmed/36899022
http://dx.doi.org/10.1038/s41467-023-37094-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006232/
https://www.ncbi.nlm.nih.gov/pubmed/36899022
http://dx.doi.org/10.1038/s41467-023-37094-8

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