Cargando…

Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence

Vascular endothelial cells (ECs) senescence correlates with the increase of cardiovascular diseases in ageing population. Although ECs rely on glycolysis for energy production, little is known about the role of glycolysis in ECs senescence. Here, we report a critical role for glycolysis-derived seri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Yinsheng, Tang, Lixu, Huang, Han, Yu, Qi, Hu, Bicheng, Wang, Gang, Ge, Feng, Yin, Tailang, Li, Shanshan, Yu, Xilan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006232/ https://www.ncbi.nlm.nih.gov/pubmed/36899022 http://dx.doi.org/10.1038/s41467-023-37094-8

Ejemplares similares

D-3-Phosphoglycerate Dehydrogenase
por: Grant, Gregory A.
Publicado: (2018)

Targeting phosphoglycerate dehydrogenase in multiple myeloma
por: Elsaadi, Samah, et al.
Publicado: (2021)

Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate and promotes histone methylation
por: Fan, Jing, et al.
Publicado: (2014)

Glc7/PP1 dephosphorylates histone H3T11 to regulate autophagy and telomere silencing in response to nutrient availability
por: Zhang, Xinyu, et al.
Publicado: (2023)

The Role of D-3-Phosphoglycerate Dehydrogenase in Cancer
por: Zhao, Xiaoya, et al.
Publicado: (2020)

Expanding the clinical spectrum of 3-phosphoglycerate dehydrogenase deficiency
por: Tabatabaie, L., et al.
Publicado: (2010)

Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth
por: Chen, Jinyun, et al.
Publicado: (2013)

Exogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT–NAD(+)–SIRT1 pathway
por: Ma, Rui, et al.
Publicado: (2019)

Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
por: Locasale, Jason W, et al.
Publicado: (2012)

Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate
por: Fan, Jing, et al.
Publicado: (2014)

Phosphoglycerate Dehydrogenase: Potential Therapeutic Target and Putative Metabolic Oncogene
por: Zogg, Cheryl K.
Publicado: (2014)

A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase
por: Mullarky, Edouard, et al.
Publicado: (2016)

Phosphoglycerate dehydrogenase positively regulates the proliferation of chicken muscle cells
por: Wang, Han, et al.
Publicado: (2022)

Biochemical and Biophysical Characterization of Recombinant Human 3-Phosphoglycerate Dehydrogenase
por: Murtas, Giulia, et al.
Publicado: (2021)

Designing Cyclic-Constrained Peptides to Inhibit Human Phosphoglycerate Dehydrogenase
por: Qing, Xiaoyu, et al.
Publicado: (2023)

Cla4 phosphorylates histone methyltransferase Set1 to prevent its degradation by the APC/C(Cdh1) complex
por: Gong, Xuanyunjing, et al.
Publicado: (2023)

Phosphoglycerate dehydrogenase is a novel predictor for poor prognosis in gastric cancer
por: Xian, Yun, et al.
Publicado: (2016)

Stromal NADH supplied by PHOSPHOGLYCERATE DEHYDROGENASE3 is crucial for photosynthetic performance
por: Höhner, Ricarda, et al.
Publicado: (2021)

Structure–Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH)
por: Spillier, Quentin, et al.
Publicado: (2020)

Association of Phosphorylated Pyruvate Dehydrogenase with Pyruvate Kinase M2 Promotes PKM2 Stability in Response to Insulin
por: Hossain, Abu Jubayer, et al.
Publicado: (2023)

Phosphorylation of Jhd2 by the Ras-cAMP-PKA(Tpk2) pathway regulates histone modifications and autophagy
por: Yu, Qi, et al.
Publicado: (2022)

PKM2 functions as a histone kinase
por: Lu, Zhimin
Publicado: (2012)

An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation
por: Mattaini, Katherine R, et al.
Publicado: (2015)

Identification and Biochemical Characterization of the Serine Biosynthetic Enzyme 3-Phosphoglycerate Dehydrogenase in Marchantia polymorpha
por: Akashi, Hiromichi, et al.
Publicado: (2018)

Novel regulatory mechanism of serine biosynthesis associated with 3-phosphoglycerate dehydrogenase in Arabidopsis thaliana
por: Okamura, Eiji, et al.
Publicado: (2017)

Identification of Novel Natural Inhibitors to Human 3-Phosphoglycerate Dehydrogenase (PHGDH) for Cancer Treatment
por: Sadiqa, Ayesha, et al.
Publicado: (2022)

Inhibition of Phosphoglycerate Dehydrogenase Radiosensitizes Human Colorectal Cancer Cells under Hypoxic Conditions
por: Van de Gucht, Melissa, et al.
Publicado: (2022)

Regulation of SESAME-mediated H3T11 phosphorylation by glycolytic enzymes and metabolites
por: Yu, Qi, et al.
Publicado: (2017)

Metabolic regulation of telomere silencing by SESAME complex-catalyzed H3T11 phosphorylation
por: Zhang, Shihao, et al.
Publicado: (2021)

Interplay Between Glucose Metabolism and Chromatin Modifications in Cancer
por: Ma, Rui, et al.
Publicado: (2021)

Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead box M1
por: Liu, Jinlong, et al.
Publicado: (2012)

Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH)
por: Unterlass, Judith E., et al.
Publicado: (2017)

Overcoming erlotinib resistance in EGFR mutation-positive lung adenocarcinomas through repression of phosphoglycerate dehydrogenase
por: Dong, Jiang-Kai, et al.
Publicado: (2018)

Diversified amino acid-mediated allosteric regulation of phosphoglycerate dehydrogenase for serine biosynthesis in land plants
por: Okamura, Eiji, et al.
Publicado: (2021)

PKM2-Induced the Phosphorylation of Histone H3 Contributes to EGF-Mediated PD-L1 Transcription in HCC
por: Wang, Xiao, et al.
Publicado: (2020)

Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2
por: Mikawa, Takumi, et al.
Publicado: (2014)

Reciprocal Regulation of Metabolic Reprogramming and Epigenetic Modifications in Cancer
por: Yu, Xilan, et al.
Publicado: (2018)

Enhanced vulnerability to oxidative stress and induction of inflammatory gene expression in 3‐phosphoglycerate dehydrogenase‐deficient fibroblasts
por: Hamano, Momoko, et al.
Publicado: (2018)

Overcoming erlotinib resistance in EGFR mutation-positive lung adenocarcinomas through repression of phosphoglycerate dehydrogenase: Erratum
por: Dong, Jiang-Kai, et al.
Publicado: (2021)

Corrigendum: PKM2-Induced the Phosphorylation of Histone H3 Contributes to EGF-Mediated PD-L1 Transcription in HCC
por: Wang, Xiao, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hqhu4v3q0g85vvvs0v38rrglpc