Decrypting the programming of β-methylation in virginiamycin M biosynthesis

During biosynthesis by multi-modular trans-AT polyketide synthases, polyketide structural space can be expanded by conversion of initially-formed electrophilic β-ketones into β-alkyl groups. These multi-step transformations are catalysed by 3-hydroxy-3-methylgluratryl synthase cassettes of enzymes....

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Detalles Bibliográficos
Autores principales: Collin, Sabrina, Cox, Russell J., Paris, Cédric, Jacob, Christophe, Chagot, Benjamin, Weissman, Kira J., Gruez, Arnaud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006238/
https://www.ncbi.nlm.nih.gov/pubmed/36899003
http://dx.doi.org/10.1038/s41467-023-36974-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006238/
https://www.ncbi.nlm.nih.gov/pubmed/36899003
http://dx.doi.org/10.1038/s41467-023-36974-3

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