A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by Mycobacterium tuberculosis Gyrase

[Image: see text] The rise in drug-resistant tuberculosis has necessitated the search for alternative antibacterial treatments. Spiropyrimidinetriones (SPTs) represent an important new class of compounds that work through gyrase, the cytotoxic target of fluoroquinolone antibacterials. The present st...

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Detalles Bibliográficos
Autores principales: Byl, Jo Ann W., Mueller, Rudolf, Bax, Ben, Basarab, Gregory S., Chibale, Kelly, Osheroff, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006343/
https://www.ncbi.nlm.nih.gov/pubmed/36802491
http://dx.doi.org/10.1021/acsinfecdis.3c00012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006343/
https://www.ncbi.nlm.nih.gov/pubmed/36802491
http://dx.doi.org/10.1021/acsinfecdis.3c00012

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