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Genetic variation in salt taste receptors impact salt intake and blood pressure

So far, few studies have examined the effect of salt taste receptors genetic variation on dietary intake in the Iranian population. We aimed to evaluate associations between single nucleotide polymorphisms (SNPs) in salt taste receptors’ genes with dietary salt intake and blood pressure. A cross-sec...

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Autores principales: Mohammadifard, Noushin, Moazeni, Faezeh, Azizian-Farsani, Fatemeh, Gharipour, Mojgan, Khosravi, Elham, Sadeghian, Ladan, Mansouri, Asieh, Shirani, Shahin, Sarrafzadegan, Nizal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006406/
https://www.ncbi.nlm.nih.gov/pubmed/36899055
http://dx.doi.org/10.1038/s41598-022-23827-0
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author Mohammadifard, Noushin
Moazeni, Faezeh
Azizian-Farsani, Fatemeh
Gharipour, Mojgan
Khosravi, Elham
Sadeghian, Ladan
Mansouri, Asieh
Shirani, Shahin
Sarrafzadegan, Nizal
author_facet Mohammadifard, Noushin
Moazeni, Faezeh
Azizian-Farsani, Fatemeh
Gharipour, Mojgan
Khosravi, Elham
Sadeghian, Ladan
Mansouri, Asieh
Shirani, Shahin
Sarrafzadegan, Nizal
author_sort Mohammadifard, Noushin
collection PubMed
description So far, few studies have examined the effect of salt taste receptors genetic variation on dietary intake in the Iranian population. We aimed to evaluate associations between single nucleotide polymorphisms (SNPs) in salt taste receptors’ genes with dietary salt intake and blood pressure. A cross-sectional study was carried out among 116 randomly selected healthy adults aged ≥ 18 in Isfahan, Iran. Participants underwent sodium intake determination by 24-h urine collection, as well as dietary assessment by semi-quantitative food frequency questionnaire and blood pressure measurement. Whole blood was collected to extract DNA and genotype of SNP rs239345 in SCNN1B and rs224534, rs4790151 and rs8065080 in TRPV1 gene. Sodium consumption and diastolic blood pressure were significantly higher in carriers of the A-allele in rs239345 compared to subjects with the TT genotype (4808.4 ± 824.4 mg/day vs. 4043.5 ± 989.3 mg/day; P = 0.004) and 83.6 ± 8.5 mmHg vs. 77.3 ± 7.3 mmHg; P = 0.011), respectively. The level of sodium intake was lower in the TT genotype of TRPV1 (rs224534) than the CC genotype (3767.0 ± 713.7 mg/day vs. 4633.3 ± 793.5 mg/day; P = 0.012). We could not find any association between genotypes of all SNPs with systolic blood pressure as well as genotypes of rs224534, rs4790151 and rs8065080 with diastolic blood pressure. Genetic variations can relate with salt intake and consequently may associate with hypertension and finally cardiovascular disease risk in the Iranian population.
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spelling pubmed-100064062023-03-12 Genetic variation in salt taste receptors impact salt intake and blood pressure Mohammadifard, Noushin Moazeni, Faezeh Azizian-Farsani, Fatemeh Gharipour, Mojgan Khosravi, Elham Sadeghian, Ladan Mansouri, Asieh Shirani, Shahin Sarrafzadegan, Nizal Sci Rep Article So far, few studies have examined the effect of salt taste receptors genetic variation on dietary intake in the Iranian population. We aimed to evaluate associations between single nucleotide polymorphisms (SNPs) in salt taste receptors’ genes with dietary salt intake and blood pressure. A cross-sectional study was carried out among 116 randomly selected healthy adults aged ≥ 18 in Isfahan, Iran. Participants underwent sodium intake determination by 24-h urine collection, as well as dietary assessment by semi-quantitative food frequency questionnaire and blood pressure measurement. Whole blood was collected to extract DNA and genotype of SNP rs239345 in SCNN1B and rs224534, rs4790151 and rs8065080 in TRPV1 gene. Sodium consumption and diastolic blood pressure were significantly higher in carriers of the A-allele in rs239345 compared to subjects with the TT genotype (4808.4 ± 824.4 mg/day vs. 4043.5 ± 989.3 mg/day; P = 0.004) and 83.6 ± 8.5 mmHg vs. 77.3 ± 7.3 mmHg; P = 0.011), respectively. The level of sodium intake was lower in the TT genotype of TRPV1 (rs224534) than the CC genotype (3767.0 ± 713.7 mg/day vs. 4633.3 ± 793.5 mg/day; P = 0.012). We could not find any association between genotypes of all SNPs with systolic blood pressure as well as genotypes of rs224534, rs4790151 and rs8065080 with diastolic blood pressure. Genetic variations can relate with salt intake and consequently may associate with hypertension and finally cardiovascular disease risk in the Iranian population. Nature Publishing Group UK 2023-03-10 /pmc/articles/PMC10006406/ /pubmed/36899055 http://dx.doi.org/10.1038/s41598-022-23827-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Mohammadifard, Noushin
Moazeni, Faezeh
Azizian-Farsani, Fatemeh
Gharipour, Mojgan
Khosravi, Elham
Sadeghian, Ladan
Mansouri, Asieh
Shirani, Shahin
Sarrafzadegan, Nizal
Genetic variation in salt taste receptors impact salt intake and blood pressure
title Genetic variation in salt taste receptors impact salt intake and blood pressure
title_full Genetic variation in salt taste receptors impact salt intake and blood pressure
title_fullStr Genetic variation in salt taste receptors impact salt intake and blood pressure
title_full_unstemmed Genetic variation in salt taste receptors impact salt intake and blood pressure
title_short Genetic variation in salt taste receptors impact salt intake and blood pressure
title_sort genetic variation in salt taste receptors impact salt intake and blood pressure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006406/
https://www.ncbi.nlm.nih.gov/pubmed/36899055
http://dx.doi.org/10.1038/s41598-022-23827-0
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