Acute toxicity and genotoxicity studies on new melatonergic antidepressant GW117

GW117, a novel derivate compound of agomelatine that acts as both a 5-HT2C receptor antagonist and a MT1/MT2 receptor agonist, likely underlines the potent antidepressant action with less hepatotoxicity than agomelatine. We evaluated the acute toxicity of GW117, and the genotoxicity of GW117 using b...

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Detalles Bibliográficos
Autores principales: Gao, Mei, Ma, Hui, Liu, Tianbin, Cao, Chong, Zheng, Zhiyong, Tang, Liansheng, Gu, Wei, Zhang, Daizhou, Sun, Haiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006472/
https://www.ncbi.nlm.nih.gov/pubmed/36915542
http://dx.doi.org/10.1016/j.heliyon.2023.e14026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006472/
https://www.ncbi.nlm.nih.gov/pubmed/36915542
http://dx.doi.org/10.1016/j.heliyon.2023.e14026

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