Cargando…

Modeling incomplete penetrance in arrhythmogenic cardiomyopathy by human induced pluripotent stem cell derived cardiomyocytes

Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) are commonly used to model arrhythmogenic cardiomyopathy (ACM), a heritable cardiac disease characterized by severe ventricular arrhythmias, fibrofatty myocardial replacement and progressive ventricular dysfunction. Although ACM...

Descripción completa

Detalles Bibliográficos
Autores principales:	De Bortoli, Marzia, Meraviglia, Viviana, Mackova, Katarina, Frommelt, Laura S., König, Eva, Rainer, Johannes, Volani, Chiara, Benzoni, Patrizia, Schlittler, Maja, Cattelan, Giada, Motta, Benedetta M., Volpato, Claudia, Rauhe, Werner, Barbuti, Andrea, Zacchigna, Serena, Pramstaller, Peter P., Rossini, Alessandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Research Network of Computational and Structural Biotechnology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006475/ https://www.ncbi.nlm.nih.gov/pubmed/36915380 http://dx.doi.org/10.1016/j.csbj.2023.02.029

Ejemplares similares

Exploring digenic inheritance in arrhythmogenic cardiomyopathy
por: König, Eva, et al.
Publicado: (2017)

Metabolic Signature of Arrhythmogenic Cardiomyopathy
por: Volani, Chiara, et al.
Publicado: (2021)

Derivation of human induced pluripotent stem cell line EURACi004-A from skin fibroblasts of a patient with Arrhythmogenic Cardiomyopathy carrying the heterozygous PKP2 mutation c.2569_3018del50
por: Ermon, Benedetta, et al.
Publicado: (2018)

Myocardial Fibrosis in Hypertrophic Cardiomyopathy: A Perspective from Fibroblasts
por: Schlittler, Maja, et al.
Publicado: (2023)

Oxidized LDL‐dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy
por: Sommariva, Elena, et al.
Publicado: (2021)

GCN5 contributes to intracellular lipid accumulation in human primary cardiac stromal cells from patients affected by Arrhythmogenic cardiomyopathy
por: Volani, Chiara, et al.
Publicado: (2022)

The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid (SAHA) Restores Cardiomyocyte Contractility in a Rat Model of Early Diabetes
por: Bocchi, Leonardo, et al.
Publicado: (2019)

The arrhythmogenic cardiomyopathy-specific coding and non-coding transcriptome in human cardiac stromal cells
por: Rainer, Johannes, et al.
Publicado: (2018)

A detailed characterization of the hyperpolarization-activated “funny” current (I(f)) in human-induced pluripotent stem cell (iPSC)–derived cardiomyocytes with pacemaker activity
por: Giannetti, Federica, et al.
Publicado: (2021)

Inflammation in the Pathogenesis of Arrhythmogenic Cardiomyopathy: Secondary Event or Active Driver?
por: Meraviglia, Viviana, et al.
Publicado: (2021)

Desmin Mutations and Arrhythmogenic Right Ventricular Cardiomyopathy
por: Lorenzon, Alessandra, et al.
Publicado: (2013)

The Impact of CRISPR/Cas9 Technology on Cardiac Research: From Disease Modelling to Therapeutic Approaches
por: Motta, Benedetta M., et al.
Publicado: (2017)

Alginate Formulations: Current Developments in the Race for Hydrogel-Based Cardiac Regeneration
por: Cattelan, Giada, et al.
Publicado: (2020)

PITX2 induction leads to impaired cardiomyocyte function in arrhythmogenic cardiomyopathy
por: van Kampen, Sebastiaan J., et al.
Publicado: (2023)

Endothelial cell–cardiomyocyte crosstalk in heart development and disease
por: Colliva, Andrea, et al.
Publicado: (2019)

Effects of smoking status, history and intensity on heart rate variability in the general population: The CHRIS study
por: Murgia, Federico, et al.
Publicado: (2019)

Arrhythmogenic Calmodulin Mutations Disrupt Intracellular Cardiomyocyte Ca(2+) Regulation by Distinct Mechanisms
por: Yin, Guo, et al.
Publicado: (2014)

Spatial transcriptomics unveils ZBTB11 as a regulator of cardiomyocyte degeneration in arrhythmogenic cardiomyopathy
por: Boogerd, Cornelis J, et al.
Publicado: (2022)

Cardiac mesenchymal stromal cells are a source of adipocytes in arrhythmogenic cardiomyopathy
por: Sommariva, E., et al.
Publicado: (2016)

Human myofibroblasts increase the arrhythmogenic potential of human induced pluripotent stem cell-derived cardiomyocytes
por: Johnson, Robert D., et al.
Publicado: (2023)

Human Cardiomyocyte Progenitor Cells in Co-culture with Rat Cardiomyocytes Form a Pro-arrhythmic Substrate: Evidence for Two Different Arrhythmogenic Mechanisms
por: Smit, Nicoline W., et al.
Publicado: (2017)

PITX2 gain-of-function mutation associated with atrial fibrillation alters mitochondrial activity in human iPSC atrial-like cardiomyocytes
por: Benzoni, Patrizia, et al.
Publicado: (2023)

Trypanosoma brucei cathepsin-L increases arrhythmogenic sarcoplasmic reticulum-mediated calcium release in rat cardiomyocytes
por: Elliott, Elspeth B., et al.
Publicado: (2013)

Cardiomyocytes generated from CPVT(D307H) patients are arrhythmogenic in response to β-adrenergic stimulation
por: Novak, Atara, et al.
Publicado: (2012)

GPER limits adverse changes to Ca(2+) signalling and arrhythmogenic activity in ovariectomised guinea pig cardiomyocytes
por: Francis, Alice J., et al.
Publicado: (2022)

Catalytic antibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin and impair cardiomyocyte cohesion
por: Yeruva, Sunil, et al.
Publicado: (2023)

Giant Thrombotic Right Coronary Aneurysm in an Infant with Undiagnosed Incomplete Kawasaki Disease and Rapidly Progressive Cardiovascular Collapse
por: Ellepola, Chalani, et al.
Publicado: (2019)

Clinical phenotype and diagnosis of arrhythmogenic right ventricular cardiomyopathy in pediatric patients carrying desmosomal gene mutations
por: Bauce, Barbara, et al.
Publicado: (2011)

VAMS-Based Blood Capillary Sampling for Mass Spectrometry-Based Human Metabolomics Studies
por: Volani, Chiara, et al.
Publicado: (2023)

Flecainide ameliorates arrhythmogenicity through NCX flux in Andersen-Tawil syndrome-iPS cell-derived cardiomyocytes
por: Kuroda, Yusuke, et al.
Publicado: (2017)

Correction: Catalytic antibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin and impair cardiomyocyte cohesion
por: Yeruva, Sunil, et al.
Publicado: (2023)

Patient-specific primary and pluripotent stem cell-derived stromal cells recapitulate key aspects of arrhythmogenic cardiomyopathy
por: Maione, Angela Serena, et al.
Publicado: (2023)

Arrhythmogenic cardiomyopathy
por: Pilichou, Kalliopi, et al.
Publicado: (2016)

Variability in gene expression underlies incomplete penetrance
por: Raj, Arjun, et al.
Publicado: (2010)

Mosaicism and incomplete penetrance of PCDH19 mutations
por: Liu, Aijie, et al.
Publicado: (2019)

Circulating miR-185-5p as a Potential Biomarker for Arrhythmogenic Right Ventricular Cardiomyopathy
por: Sacchetto, Claudia, et al.
Publicado: (2021)

HiPSC-derived cardiomyocyte to model Brugada syndrome: both asymptomatic and symptomatic mutation carriers reveal increased arrhythmogenicity
por: Penttinen, Kirsi, et al.
Publicado: (2023)

Arrhythmogenic cardiomyopathy as a myogenic disease: highlights from cardiomyocytes derived from human induced pluripotent stem cells
por: Reisqs, J. B., et al.
Publicado: (2023)

HDAC Inhibition Improves the Sarcoendoplasmic Reticulum Ca(2+)-ATPase Activity in Cardiac Myocytes
por: Meraviglia, Viviana, et al.
Publicado: (2018)

Metabolic Signature of Dietary Iron Overload in a Mouse Model
por: Volani, Chiara, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_qbbh3l9858aa2epr0a7frhnq48