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Translational characterization of the temporal dynamics of metabolic dysfunctions in liver, adipose tissue and the gut during diet-induced NASH development in Ldlr−/−.Leiden mice
BACKGROUND: NAFLD progression, from steatosis to inflammation and fibrosis, results from an interplay of intra- and extrahepatic mechanisms. Disease drivers likely include signals from white adipose tissue (WAT) and gut. However, the temporal dynamics of disease development remain poorly understood....
Autores principales: | Gart, Eveline, van Duyvenvoorde, Wim, Snabel, Jessica M., de Ruiter, Christa, Attema, Joline, Caspers, Martien P.M., Lek, Serene, van Heuven, Bertie Joan, Speksnijder, Arjen G.C.L., Giera, Martin, Menke, Aswin, Salic, Kanita, Bence, Kendra K., Tesz, Gregory J., Keijer, Jaap, Kleemann, Robert, Morrison, Martine C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006542/ https://www.ncbi.nlm.nih.gov/pubmed/36915476 http://dx.doi.org/10.1016/j.heliyon.2023.e13985 |
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