Structural and dynamic determinants for highly selective RET kinase inhibition reveal cryptic druggability

INTRODUCTION: The structural and dynamic determinants that confer highly selective RET kinase inhibition are poorly understood. OBJECTIVES: To explore the druggability landscape of the RET active site in order to uncover structural and dynamic vulnerabilities that can be therapeutically exploited. M...

Descripción completa

Detalles Bibliográficos
Autores principales: Shehata, Moustafa A., Contreras, Julia, Martín-Hurtado, Ana, Froux, Aurane, Mohamed, Hossam Taha, El-Sherif, Ahmed A., Plaza-Menacho, Iván
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006619/
https://www.ncbi.nlm.nih.gov/pubmed/35595215
http://dx.doi.org/10.1016/j.jare.2022.05.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006619/
https://www.ncbi.nlm.nih.gov/pubmed/35595215
http://dx.doi.org/10.1016/j.jare.2022.05.004

Ejemplares similares