The hereditary N363K POLE exonuclease mutant extends PPAP tumor spectrum to glioblastomas by causing DNA damage and aneuploidy in addition to increased mismatch mutagenicity

The exonuclease domain of DNA polymerases epsilon's catalytic subunit (POLE) removes misincorporated nucleotides, called proofreading. POLE-exonuclease mutations cause colorectal- and endometrial cancers with an extreme burden of single nucleotide substitutions. We recently reported that partic...

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Detalles Bibliográficos
Autores principales: Labrousse, Guillaume, Vande Perre, Pierre, Parra, Genis, Jaffrelot, Marion, Leroy, Laura, Chibon, Frederic, Escudie, Frederic, Selves, Janick, Hoffmann, Jean-Sebastien, Guimbaud, Rosine, Lutzmann, Malik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
DNA Damage Sensing and Repair
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006997/
https://www.ncbi.nlm.nih.gov/pubmed/36915289
http://dx.doi.org/10.1093/narcan/zcad011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006997/
https://www.ncbi.nlm.nih.gov/pubmed/36915289
http://dx.doi.org/10.1093/narcan/zcad011

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