MMP-2 Silencing through siRNA Loaded Positively-Charged Nanoparticles (AcPEI-NPs) Counteracts Chondrocyte De-Differentiation

The abnormal matrix remodeling process, as well as inflammation, angiogenesis, and tumor metastasis, are related to an increase in the synthesis and secretion of matrix metalloproteinases (MMPs), the zinc-dependent proteolytic endopeptidases. Recent studies have evidenced MMPs’ role in osteoarthriti...

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Detalles Bibliográficos
Autores principales: Conte, Raffaele, Finicelli, Mauro, Borrone, Alessia, Margarucci, Sabrina, Peluso, Gianfranco, Calarco, Anna, Bosetti, Michela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007186/
https://www.ncbi.nlm.nih.gov/pubmed/36904410
http://dx.doi.org/10.3390/polym15051172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007186/
https://www.ncbi.nlm.nih.gov/pubmed/36904410
http://dx.doi.org/10.3390/polym15051172

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